Ƥϸƹ˾Castle Creek7500ԪͶ
ƹ˾Castle Creek Biosciences˾7500ԪͶƽƹаٴεFCX-007һӪԴԱƤɽ֢(RDEB)ߵĺѡҩͬʱչλڷѳǵcGMPƶƷء
Castle Creek BiosciencesһΪŴԼƹ¶ҩĹ˾Ʒ߳RDEBضӲƤ֢SclerodermaԱƤɽ(epidermolysis bullosa simplexEBS)ŴƤ
Castle CreekϯִйJohn MaslowskiһݱCastle CreekԺܻ¼Ͷߵս֧⽫ƶı仼ߵõҽѧδ
ϤЩͶеIJʽ֧RDEBFCX-007ٴ(NCT04213261)ٴ齫20RDEBĶͯͳпչĿΪȹŰƷFCX-007ƷʹǷܸ˿ϡٴλڰ˹͡Dell Children 's Medical GroupļδٴĴšCastle Creek 2021 FCX-007ϵ
RDEBһƤһƤˮݲۼȫΪвŴƤᵼ¶ͯRDEBߵCOL7A1ȱʹЧԵVIIͽԭѰڸ֯ṹǿοƤͱƤϸ뿴ƤơǷRenovaCareKCLRDEBĻ
Castle CreekչFCX-007ƹһֻϸҪͨ综Ƥάϸлˢʹ䱬ЧCOL7˺Щϸֱ͵Լˮݺ˿ϣܹ˿ϲճƤ㡣ˢµϸܹȽӦƷƽ˷ܵھеI/IIٴ(NCT02810951)Чʾ4RDEBƺһ˿ȫϡ
FCX-007, Castle CreekڿԴCCP-020ҩһEBSҩкпDiacereinһIIٴоЧʾCCP-020ҩΧEBSߵƤˮ̭60%ڱ15%ͬʱиöء
John MaslowskiǶԴԱƤɽ֢ƷǼᶨƵǻһĿĿϣFCX-007CCP-020ͬʱUGƽ̨Ĺģ
ڴParagon Biosciences Ͷ 5500 ԪĹȨͶFidelity ManagementResearch Company Valor Equity Partners Ͷ Horizon Technology Finance Corporation ṩ 2000 ԪΣ
Paragon Biosciencesһ֥ӸҽҩͶʡҩ￪˾רעҩ AI տѧصIJƷͬʱȽϸͻƷȡԴ˴ͶParagon Biosciences³ϯִйٽJeffery AroninǶCastle CreekȡõϣӦ˷ЭCastle Creekѧƽ̨ԽĻ
ΪһͻϸƹҵCDMOЧ˾UG ṩעٴоͲҩٴ걨ƻٴƷҵGMPЧ漰ƷϸزͻͬʱӴҩ￪
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